Iron-Catalyzed, Chelation-Induced Remote C–H Allylation of Quinolines via 8‑Amido Assistance
datasetposted on 18.07.2014 by Xuefeng Cong, Xiaoming Zeng
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An iron-catalyzed, 8-amido-enabled regiodivergent C–H allylation of quinolines is described. This reaction represents a rare example of chelation-induced geometrically inaccessible C–H functionalization, allowing for the highly regio- and stereoselective preparation of either the C5- or the C4-allylated quinoline scaffolds regiocontrolled by the catalytic systems.