Iron-Catalyzed Regioselective Remote C(sp2)‑H Carboxylation of Naphthyl and Quinoline Amides
datasetposted on 02.08.2019, 17:35 by Sandeep Kumar, Sourav Pradhan, Subhasish Roy, Pinaki Bhusan De, Tharmalingam Punniyamurthy
Iron(III)-catalyzed regioselective direct remote C–H carboxylation of naphthyl and quinoline amides was developed using CBr4 and alcohol. The reaction involves a radical pathway using a coordination activation strategy and single electron transfer process. The use of sustainable iron catalysis, selectivity, and the substrate scope are the important practical features.