cs1c00714_si_005.cif (111.59 kB)

Iridium(III)-Catalyzed Branch-Selective C–H Alkenylation of Aniline Derivatives with Alkenes

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posted on 20.04.2021, 19:15 by Shrikant M. Khake, Ken Yamazaki, Yusuke Ano, Naoto Chatani
The branch-selective C–H alkenylation with alkenes using an iridium catalyst is reported. The Ir­(III)-catalyzed reaction of aniline derivatives that contain a pyrimidine-directing group with vinylsilanes and terminal aliphatic alkenes results in branch-selective C–H alkenylation. The reaction provides a broad substrate scope for aniline derivatives, and a variety of functional groups are tolerated. Density functional theory calculations were performed in an attempt to understand the origin of the branch selectivity.