Iridium-Catalyzed Asymmetric Hydrogenation of 2H‑Chromenes: A Highly Enantioselective Approach to Isoflavan Derivatives
datasetposted on 31.08.2017, 00:30 by Jingzhao Xia, Yu Nie, Guoqiang Yang, Yangang Liu, Wanbin Zhang
A highly efficient (aS)-Ir/In-BiphPHOX-catalyzed asymmetric hydrogenation of substituted 2H-chromenes and substituted benzo[e][1,2]oxathiine 2,2-dioxides is described. A series of 2H-chromenes and benzo[e][1,2]oxathiine 2,2-dioxides were hydrogenated to give the target products in high yields (92–99%) with excellent enantioselectivities (up to 99.7% ee) using our catalytic system. This reaction provides a direct and efficient method for the construction of chiral benzo six-membered oxygen-containing compounds.