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Iridium-Catalyzed Asymmetric Hydrogenation of 2H‑Chromenes: A Highly Enantioselective Approach to Isoflavan Derivatives

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posted on 31.08.2017, 00:30 by Jingzhao Xia, Yu Nie, Guoqiang Yang, Yangang Liu, Wanbin Zhang
A highly efficient (aS)-Ir/In-BiphPHOX-catalyzed asymmetric hydrogenation of substituted 2H-chromenes and substituted benzo­[e]­[1,2]­oxathiine 2,2-dioxides is described. A series of 2H-chromenes and benzo­[e]­[1,2]­oxathiine 2,2-dioxides were hydrogenated to give the target products in high yields (92–99%) with excellent enantioselectivities (up to 99.7% ee) using our catalytic system. This reaction provides a direct and efficient method for the construction of chiral benzo six-membered oxygen-containing compounds.

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