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Ion Channel-like Crystallographic Signatures in Modified Guanine–Potassium/Sodium Interactions

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posted on 06.02.2013, 00:00 by N. Nagapradeep, Suneeta Sharma, Sandeep Verma
This communication describes crystallographic details of structures reminiscent of ion channels, formed from regioisomeric N7 and N9 guanine-carboxylate conjugates with potassium/sodium ions and their subsequent STM observations on Au(111) surface. Ion channel-like crystal structures were obtained with the observation of a notable shift in metal ion coordination from carbonyl to carboxylate oxygen. These results are expected to provide insight into competing sites for modified guanine–metal coordination, an entry into guanine-based ion channels and a route toward guanine-functionalized surfaces.