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Indole Diterpenoid Synthetic Studies. Construction of the Heptacyclic Core of (−)-Nodulisporic Acid D

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posted on 13.04.2006, 00:00 authored by Amos B. Smith, Akin H. Davulcu, László Kürti
Construction of the heptacyclic core of (−)-nodulisporic acid D, a representative member of a recently discovered class of architecturally complex, ectoparasiticidal indole alkaloids, has been achieved. The modular synthetic strategy comprises an expedient, stereocontrolled synthesis of a tricyclic western hemisphere, in conjunction with union of an eastern hemisphere, exploiting the 2-substituted indole synthetic protocol introduced and developed in our laboratory.