I2–TBHP-Catalyzed Oxidative Cross-Coupling of N‑Sulfonyl Hydrazones and Isocyanides to 5‑Aminopyrazoles
dataset
posted on 2015-03-20, 00:00 authored by Gopal
Chandru Senadi, Wan-Ping Hu, Ting-Yi Lu, Amol Milind Garkhedkar, Jaya Kishore Vandavasi, Jeh-Jeng WangI2–TBHP-catalyzed
oxidative cross coupling of N-sulfonyl hydrazones
with isocyanides has been realized
for the synthesis of 5-aminopyrazoles through formal [4 + 1] annulation
via in situ azoalkene formation. Notable features are the metal/alkyne-free
strategy, C–C and C–N bond formation, atom economy,
catalytic I2, broad functional group tolerance, good reaction
yields, shorter time, and also applicability to one-pot methodology.
