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I2‑Catalyzed Oxidative Coupling Reactions of Hydrazones and Amines and the Application in the Synthesis of 1,3,5-Trisubstituted 1,2,4-Triazoles

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posted on 25.02.2016 by Zhengkai Chen, Hongli Li, Weipeng Dong, Maozhong Miao, Hongjun Ren
A general and expeditious approach for the metal-free mediated synthesis of 1,3,5-trisubstituted 1,2,4-triazoles from hydrazones and aliphatic amines has been achieved under aerobic oxidative conditions. The reaction proceeds through a cascade C–H functionalization, double C–N bonds formation, and oxidative aromatization sequence.