posted on 2013-12-06, 00:00authored byQing-Long Xu, Chun-Xiang Zhuo, Li-Xin Dai, Shu-Li You
A highly enantioselective synthesis of substituted tetrahydrocarbolines via Ir-catalyzed Friedel–Crafts type intramolecular asymmetric allylic alkylation of 2-indolyl allyl carbonates has been developed. This strategy features excellent chemoselectivity and enantioselectivity, mild reaction conditions, and an easily accessed chiral ligand.