American Chemical Society
ol4027717_si_002.cif (22.68 kB)

Highly Enantioselective Synthesis of Tetrahydrocarbolines via Iridium-Catalyzed Intramolecular Friedel–Crafts Type Allylic Alkylation Reactions

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posted on 2013-12-06, 00:00 authored by Qing-Long Xu, Chun-Xiang Zhuo, Li-Xin Dai, Shu-Li You
A highly enantioselective synthesis of substituted tetrahydrocarbolines via Ir-catalyzed Friedel–Crafts type intramolecular asymmetric allylic alkylation of 2-indolyl allyl carbonates has been developed. This strategy features excellent chemoselectivity and enantioselectivity, mild reaction conditions, and an easily accessed chiral ligand.