ol500157b_si_002.cif (961.44 kB)

Highly Enantioselective Organocatalyzed Vinylogous Michael-Type Reaction for the Construction of Trifluoromethylated All-Carbon Quaternary Stereocenters

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posted on 07.03.2014, 00:00 by Qiao Chen, Guoqiang Wang, Xianxing Jiang, Zhaoqing Xu, Li Lin, Rui Wang
The first example of a highly enantioselective vinylogous Michael-type reaction of β,β-disubstituted nitroalkenes is disclosed. A series of biologically important chiral oxindoles, featuring a trifluoromethylated all-carbon quaternary chiral center, were obtained in good yields with excellent enantioselectivities (up to >99% ee).