ol500157b_si_002.cif (961.44 kB)
Highly Enantioselective Organocatalyzed Vinylogous Michael-Type Reaction for the Construction of Trifluoromethylated All-Carbon Quaternary Stereocenters
dataset
posted on 2014-03-07, 00:00 authored by Qiao Chen, Guoqiang Wang, Xianxing Jiang, Zhaoqing Xu, Li Lin, Rui WangThe first example of a highly enantioselective
vinylogous Michael-type
reaction of β,β-disubstituted nitroalkenes is disclosed.
A series of biologically important chiral oxindoles, featuring a trifluoromethylated
all-carbon quaternary chiral center, were obtained in good yields
with excellent enantioselectivities (up to >99% ee).