American Chemical Society
ol900373z_si_002.cif (21.66 kB)

Highly Enantioselective Construction of Axial Chirality by Palladium-Catalyzed Cycloisomerization of N-Alkenyl Arylethynylamides

Download (21.66 kB)
posted on 2009-04-16, 00:00 authored by Hidetomo Imase, Takeshi Suda, Yu Shibata, Keiichi Noguchi, Masao Hirano, Ken Tanaka
A cationic palladium(II)/(S)-xyl-Segphos complex catalyzes enantioselective cycloisomerizations of N-alkenyl arylethynylamides leading to axially chiral 4-aryl-2-pyridones in high yields with high ee values. The present catalysis represents the first enantioselective construction of axial chirality by the transition-metal-catalyzed cycloisomerization.