American Chemical Society
ol101607z_si_002.cif (14.81 kB)

Highly Efficient and Expedient Synthesis of 5-Hydroxy-1H-pyrrol-2-(5H)-ones from FeCl3-Catalyzed Tandem Intramolecular Enaminic Addition of Tertiary Enamides to Ketones and 1,3-Hydroxy Rearrangement

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posted on 2010-09-03, 00:00 authored by Luo Yang, Chuan-Hu Lei, De-Xian Wang, Zhi-Tang Huang, Mei-Xiang Wang
Catalyzed by FeCl3 under very mild conditions, tertiary enamides underwent a highly efficient intramolecular enaminic addition reaction to the ketonic carbonyls followed by 1,3-hydroxy rearrangement to produce 5-hydroxy-1H-pyrrol-2(5H)-ones in excellent yields.