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Halocyclization of Unsaturated Guanidines Mediated by Koser’s Reagent and Lithium Halides

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posted on 06.11.2015, 00:00 authored by Marion Daniel, Florent Blanchard, Sophie Nocquet-Thibault, Kevin Cariou, Robert H. Dodd
The synthesis of halogenated cyclic guanidines through iodine­(III)-mediated umpolung of halide salts is described. Cyclic guanidines of various sizes can be obtained with generally excellent regioselectivities through either a chloro- or a bromocyclization, using Koser’s reagent and the corresponding lithium salt.

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