Gold vs Rhodium Catalysis: Tuning Reactivity through Catalyst Control in the C–H Alkynylation of Isoquinolones
datasetposted on 17.02.2016 by Aslam C. Shaikh, Dinesh R. Shinde, Nitin T. Patil
Datasets usually provide raw data for analysis. This raw data often comes in spreadsheet form, but can be any collection of data, on which analysis can be performed.
A site-selective C-4/C-8 alkynylation of isoquinolones catalyzed by gold and rhodium complexes is reported. A broad range of synthetically useful functional groups (−F, −Cl, −Br, −CF3, −OMe, alkyl, etc.) were tolerated, providing an efficient and robust protocol for the synthesis either C-4- or C-8-alkynylated isoquinolones.