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Gold-Mediated Synthesis and Functionalization of Chiral Halopyridones

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posted on 2013-08-16, 00:00 authored by Khanh Hung Nguyen, Sophie Tomasi, Myriam Le Roch, Loïc Toupet, Jacques Renault, Philippe Uriac, Nicolas Gouault
A rapid and efficient one-step halopyridone synthesis has been developed based on gold-catalyzed cyclization of β-amino-ynone intermediates and halodeauration process.