jo6b00346_si_002.cif (280.87 kB)

Gold(I)-Catalyzed Cascade Hydroarylation/Cycloaromatization to Indolizines via Pyridine Ring Construction

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posted on 01.04.2016, 00:00 by Xiangdong Li, Xin Xie, Yuanhong Liu
An efficient and atom-economic method for the synthesis of multisubstituted indolizines via gold-catalyzed cascade hydroarylation/​cycloaromatization reaction of α-(N-pyrrolyl)­ketones with alkynes is described. The reaction is realized through the construction of the pyridine ring of indolizines, which allows the regioselective incorporation of a wide range of functionalities on the pyridine unit.