American Chemical Society
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Gneyulins A and B, Stilbene Trimers, and Noidesols A and B, Dihydroflavonol-C-Glucosides, from the Bark of Gnetum gnemonoides

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posted on 2010-04-23, 00:00 authored by Yoko Shimokawa, Yusuke Akao, Yusuke Hirasawa, Khalijah Awang, A. Hamid A. Hadi, Seizo Sato, Chihiro Aoyama, Jiro Takeo, Motoo Shiro, Hiroshi Morita
Gneyulins A (1) and B (2), two new stilbene trimers consisting of oxyresveratrol constituent units, and noidesols A (3) and B (4), two new dihydroflavonol-C-glucosides, were isolated from the bark of Gnetum gnemonoides. The structures and configurations of 14 were elucidated on the basis of 2D NMR correlations and X-ray analysis. Gneyulins A (1) and B (2) showed inhibition of Na+-glucose transporters (SGLT-1 and SGLT-2).