American Chemical Society
ol5014153_si_004.cif (177.91 kB)

General Route for Preparing β‑Nitrocarbonyl Compounds Using Copper Thermal Redox Catalysis

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posted on 2015-12-17, 02:31 authored by Amber A. S. Gietter, Peter G. Gildner, Andrew P. Cinderella, Donald A. Watson
Using a simple copper catalyst, the alkylation of nitroalkanes with α-bromocarbonyls is now possible. This method provides a general, functional group tolerant route to β-nitrocarbonyl compounds, including nitro amides, esters, ketones, and aldehydes. The highly sterically dense, functional group rich products from these reactions can be readily elaborated into a range of complex nitrogen-containing molecules, including highly substituted β-amino acids.