American Chemical Society
ol3026796_si_004.cif (17.62 kB)

Gassman’s Cationic [2 + 2] Cycloadditions Using Temporary Tethers

Download (17.62 kB)
posted on 2016-02-20, 07:33 authored by Jun Deng, Richard P. Hsung, Changhong Ko
An intermolecular equivalent of Gassman’s cationic [2 + 2] cycloaddition through the use of temporary tethering is described. Notably, hydrazine and hydroxyamide proved to be robust under the acidic conditions required for the cycloaddition, leading to unique cyclobutane manifolds in a highly regio- and stereoselective manner. This development represents a rare usage of hydrazine and hydroxyamide in the capacity as temporary tethers.