American Chemical Society
jo9b00729_si_002.cif (588.02 kB)

Formation of Methylene Linkage for N‑Heterocycles: Sequential C–H and C–O Bond Functionalization of Methanol with Cosolvent Water

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posted on 2019-05-15, 00:00 authored by Na Li, Jinku Bai, Xiaolin Zheng, Honghua Rao
An iron-catalyzed methylene forming strategy is disclosed through sequential C–H and C–O bond functionalization of methanol with cosolvent water. This protocol provides an easy and novel access to methylene-tethered imidazo­[1,2-a]­pyridine and 2-aminopyridine analogues in a sustainable manner and represents a complementary approach to traditional methylene forming strategies.