jo9b00729_si_002.cif (588.02 kB)
Formation of Methylene Linkage for N‑Heterocycles: Sequential C–H and C–O Bond Functionalization of Methanol with Cosolvent Water
datasetposted on 2019-05-15, 00:00 authored by Na Li, Jinku Bai, Xiaolin Zheng, Honghua Rao
An iron-catalyzed methylene forming strategy is disclosed through sequential C–H and C–O bond functionalization of methanol with cosolvent water. This protocol provides an easy and novel access to methylene-tethered imidazo[1,2-a]pyridine and 2-aminopyridine analogues in a sustainable manner and represents a complementary approach to traditional methylene forming strategies.