jo9b00729_si_002.cif (588.02 kB)
Download fileFormation of Methylene Linkage for N‑Heterocycles: Sequential C–H and C–O Bond Functionalization of Methanol with Cosolvent Water
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posted on 2019-05-15, 00:00 authored by Na Li, Jinku Bai, Xiaolin Zheng, Honghua RaoAn iron-catalyzed
methylene forming strategy is disclosed through
sequential C–H and C–O bond functionalization of methanol
with cosolvent water. This protocol provides an easy and novel access
to methylene-tethered imidazo[1,2-a]pyridine and
2-aminopyridine analogues in a sustainable manner and represents a
complementary approach to traditional methylene forming strategies.