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Folding-Generated Molecular Tubes Containing One-Dimensional Water Chains

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posted on 13.01.2016, 00:00 authored by Hae-Geun Jeon, Jin Young Jung, Philjae Kang, Moon-Gun Choi, Kyu-Sung Jeong
A series of indolo­carbazole–pyridine (IP) oligomers were prepared that fold into helical conformations, and their folding features in solution and in the solid state were revealed. Helical folding of these IP foldamers is induced by dipolar interactions through the ethynyl bond and π-stacking between two repeating units. Upon helical folding, 1H NMR signals of aromatic protons were significantly shifted upfield by Δδ = 0.5–2.2 ppm. In addition, hypochromic shifts and fluorescence quenching were observed in the absorption and emission spectra. X-ray crystal structures clearly demonstrated that IP foldamers folded to helical structures with cylindrical internal cavities wherein 3 or 5 water molecules were occupied by hydrogen-bonding interactions in a 1-D array, reminiscent of transmembrane water channels, called aquaporins.