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Facile Synthesis of Acridine Derivatives by ZnCl2‑Promoted Intramolecular Cyclization of o‑Arylaminophenyl Schiff Bases

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posted on 03.01.2014, 00:00 by Qing Su, Pei Li, Mina He, Qiaolin Wu, Ling Ye, Ying Mu
A concise and efficient method for the synthesis of a wide range of acridine derivatives and polycyclic aza-aromatic compounds from a ZnCl2-promoted cyclization reaction of readily available o-arylaminophenyl Schiff base compounds under convenient conditions was developed. Reaction conditions and scope of the new method were examined in detail.