jo902324h_si_002.cif (12.85 kB)

Facile Syntheses of Enantiopure 3-Hydroxypiperidine Derivatives and 3-Hydroxypipecolic Acids

Download (12.85 kB)
posted on 05.03.2010, 00:00 by Wen-Hua Chiou, Gau-Hong Lin, Chih-Wei Liang
Facile syntheses of enantiopure trans- and cis-3-hydroxypiperidine derivatives and 3-hydroxypipecolic acids are reported, featuring Rh-catalyzed cyclohydrocarbonylation through common intermediates. A diaxial conformation in a 2,3-disubstituted N-Boc-piperidinyl structure is revealed by an X-ray crystallographic analysis.