American Chemical Society
ol0526367_si_002.cif (18.26 kB)

Facile Construction of the Pentacyclic Framework of Subincanadine B. Synthesis of 20-Deethylenylated Subincanadine B and 19,20-Dihydrosubincanadine B

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posted on 2006-01-05, 00:00 authored by Yanqin Liu, Shengjun Luo, Xingnian Fu, Fang, Zeyang Zhuang, Wanting Xiong, Xueshun Jia, Hongbin Zhai
We describe a facile approach for effectively constructing the pentacyclic framework of subincanadine B. The seven-step assembly of tetracyclic ketone 14 featured Michael addition, Pictet−Spengler cyclization, and Dieckmann condensation. From this key ketone intermediate, two analogues of subincanadine B, i.e., 20-deethylenylated subincanadine B (27) and 19,20-dihydrosubincanadine B (31), were synthesized in four steps, respectively.