Facile Assembly of Chiral Tetrahydrothiopyrans Containing Four Consecutive Stereocenters via an Organocatalytic Enantioselective Michael–Michael Cascade
datasetposted on 07.02.2014 by Shengzheng Wang, Yongqiang Zhang, Guoqiang Dong, Shanchao Wu, Kun Fang, Zhengang Li, Zhenyuan Miao, Jianzhong Yao, Hao Li, Jian Li, Wannian Zhang, Wei Wang, Chunquan Sheng
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An organocatalytic enantioselective Michael–Michael cascade reaction has been implemented for the creation of structurally variant chiral tetrahydrothiopyrans. The process is realized by employment of new bifunctional ketothioether enones and proceeds highly enantioselectively with formation of four consecutive stereogenic centers.