ol5020027_si_004.cif (15 kB)

Ethylene Transposition: Ruthenium Hydride Catalyzed Intramolecular trans-Silylvinylation of Internal Alkynes

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posted on 05.09.2014, 00:00 by Shasha Liu, Jinbo Zhao, Lauren Kaminsky, Robert J. Wilson, Nadia Marino, Daniel A. Clark
A highly selective intramolecular trans-silylvinylation of internal alkynes catalyzed by RuHCl­(CO)­(SIMes)­(PPh3) has been accomplished. The use of methyl vinyl ketone as an additive increased the efficiency of this transformation. This process was used to successfully form five-, six-, and seven-membered oxasilacycles by a formal anti-exo-dig cyclization.