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Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from Ervatamia divaricata

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posted on 17.07.2018, 00:00 by Zhi-Wen Liu, Jian Zhang, Song-Tao Li, Ming-Qun Liu, Xiao-Jun Huang, Yun-Lin Ao, Chun-Lin Fan, Dong-Mei Zhang, Qing-Wen Zhang, Wen-Cai Ye, Xiao-Qi Zhang
Ervadivamines A (1) and B (2), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from Ervatamia divaricata. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C–C and C–N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In addition, compound 1 exhibited significant cytotoxicity against four cancer cells.