jo034807w_si_003.cif (38.55 kB)

Epoxidation of Chiral Camphor N-Enoylpyrazolidinones with Methyl(trifluoromethyl)dioxirane and Urea Hydrogen Peroxide/Acid Anhydride:  Reversal of Stereoselectivity

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posted on 12.12.2003, 00:00 by Chai Ling Fan, Wei-Der Lee, Nai-Wei Teng, Ying-Chieh Sun, Kwunmin Chen
Both diastereomeric isomers of epoxides with high optical purity are obtained when camphor N-methacryloylpyrazolidinone (1a) and N-tigloylpyrazolidinone (1b) are treated with a urea hydrogen peroxide/TFAA and methyl(trifluoromethyl)dioxirane, respectively.