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Epicoccins A–D, Epipolythiodioxopiperazines from a Cordyceps-Colonizing Isolate of Epicoccum nigrum

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posted on 28.09.2007 by Yonggang Zhang, Shuchun Liu, Yongsheng Che, Xingzhong Liu
Epicoccins A–D (14), four unique epipolythiodioxopiperazines possessing unusual sulfur bridges, have been isolated from cultures of a Cordyceps-colonizing isolate of Epicoccum nigrum. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. The relative and absolute configuration of epicoccin A (1) was established by single-crystal X-ray diffraction analysis. Epicoccin A (1) showed modest antimicrobial activity.