American Chemical Society
ja043782v_si_001.cif (22.43 kB)

Enantioselective Tandem Michael Addition/H2-Hydrogenation Catalyzed by Ruthenium Hydride Borohydride Complexes Containing β-aminophosphine Ligands

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posted on 2005-01-19, 00:00 authored by Rongwei Guo, Robert H. Morris, Datong Song
A variety of ruthenium(II) catalyst precursors containing β-aminophosphine ligands and a borohydride ligand were found to be active for a one-pot, tandem asymmetric Michael addition/H2-hydrogenation reaction to give the chiral alcohol in excellent diastereomeric excess. The most effective catalyst is 4b, containing the (S)-binap ligand and (R,R)-Pnor ligand, derived from (1S,2R)-norephedrine.