posted on 2016-02-20, 09:45authored bySumit
K. Ray, Pradeep K. Singh, Nagaraju Molleti, Vinod K. Singh
A potential pharmacologically active chiral 3-substituted
4-hydroxy-2-oxo-2H-chromene skeleton has been synthesized
by enantioselective Michael addition catalyzed by PYBOX-DIPH-Zn(OTf)2 complex. The methodology has successfully been employed in
the synthesis of (R)-Warfarin and another related
compounds.