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Enantioselective Synthesis of Coumarin Derivatives by PYBOX-DIPH-Zn(II) Complex Catalyzed Michael Reaction

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posted on 2016-02-20, 09:45 authored by Sumit K. Ray, Pradeep K. Singh, Nagaraju Molleti, Vinod K. Singh
A potential pharmacologically active chiral 3-substituted 4-hydroxy-2-oxo-2H-chromene skeleton has been synthesized by enantioselective Michael addition catalyzed by PYBOX-DIPH-Zn­(OTf)2 complex. The methodology has successfully been employed in the synthesis of (R)-Warfarin and another related compounds.

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