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Enantioselective Synthesis of Cephalimysins B and C

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posted on 2017-02-03, 16:50 authored by David Chalupa, Petra Vojáčková, Jiří Partl, Dražen Pavlović, Marek Nečas, Jakub Švenda
The first synthesis of cephalimysins B and C is reported. The route features a Ni­(II)–diamine-catalyzed enantioselective conjugate addition of a densely substituted 3­(2H)-furanone and an efficient dihydroxylation–lactonization sequence as key steps in the assembly of the spirocyclic core. The fully synthetic strategy is amenable to analog preparation.

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