Enantioselective Synthesis of Cephalimysins B and C
datasetposted on 2017-02-03, 16:50 authored by David Chalupa, Petra Vojáčková, Jiří Partl, Dražen Pavlović, Marek Nečas, Jakub Švenda
The first synthesis of cephalimysins B and C is reported. The route features a Ni(II)–diamine-catalyzed enantioselective conjugate addition of a densely substituted 3(2H)-furanone and an efficient dihydroxylation–lactonization sequence as key steps in the assembly of the spirocyclic core. The fully synthetic strategy is amenable to analog preparation.