ja8b12566_si_002.cif (1.07 MB)

Enantioselective Synthesis of Azamerone

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posted on 01.02.2019, 00:00 by Matthew L. Landry, Grace M. McKenna, Noah Z. Burns
A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of natural-product-relevant chiral organochlorides motivated the development of unique strategies for accessing these motifs in enantioenriched forms. The route features a novel enantioselective chloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic hemiester, and a late-stage tetrazine [4+2]-cycloaddition/oxidation cascade.