ja6b12443_si_008.cif (1.53 MB)

Enantioselective Synthesis of [6]Carbohelicenes

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posted on 23.01.2017, 19:23 by Elisa González-Fernández, Leo D. M. Nicholls, Lukas D. Schaaf, Christophe Farès, Christian W. Lehmann, Manuel Alcarazo
The use of α-cationic phosphonites derived from TADDOL as ancillary ligands has allowed a highly regio- and enantioselective synthesis of substituted [6]­carbohelicenes by sequential Au-catalyzed intramolecular hydroarylation of diynes. Key for these results is the modular structure of these new ligands, and the enhanced reactivity that they impart to Au­(I)-centers after coordination.