jo201334n_si_001.cif (16.7 kB)
Enantioselective Synthesis of 4-Substituted 4,5-Dihydro-1H-[1,5]benzodiazepin-2(3H)-ones by the Lewis Base-Catalyzed Hydrosilylation
dataset
posted on 2016-02-22, 17:03 authored by Xing Chen, Yongsheng Zheng, Chang Shu, Weicheng Yuan, Bo Liu, Xiaomei ZhangEnantioselective synthesis of 4-substituted 4,5-dihydro-1H-[1,5]benzodiazepin-2(3H)-ones has been
accomplished through chiral Lewis base-catalyzed hydrosilylation.
The corresponding products were obtained in excellent yields (up to
99%) and enantioselectivities (up to 98%). The absolute configuration
of product 3n has been determined as S by X-ray crystallographic analysis.
