American Chemical Society
jo201334n_si_001.cif (16.7 kB)

Enantioselective Synthesis of 4-Substituted 4,5-Dihydro-1H-[1,5]benzodiazepin-2(3H)-ones by the Lewis Base-Catalyzed Hydrosilylation

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posted on 2016-02-22, 17:03 authored by Xing Chen, Yongsheng Zheng, Chang Shu, Weicheng Yuan, Bo Liu, Xiaomei Zhang
Enantioselective synthesis of 4-substituted 4,5-dihydro-1H-[1,5]­benzodiazepin-2­(3H)-ones has been accomplished through chiral Lewis base-catalyzed hydrosilylation. The corresponding products were obtained in excellent yields (up to 99%) and enantioselectivities (up to 98%). The absolute configuration of product 3n has been determined as S by X-ray crystallographic analysis.