ol501464e_si_001.cif (14.08 kB)

Enantioselective Rhodium-Catalyzed Arylation of Cyclic N‑Sulfamidate Alkylketimines: A New Access to Chiral β‑Alkyl-β-aryl Amino Alcohols

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posted on 20.06.2014, 00:00 by Ya-Jing Chen, Ya-Heng Chen, Chen-Guo Feng, Guo-Qiang Lin
The enantioselective rhodium-catalyzed 1,2-addition of arylboronates to cyclic N-sulfamidate alkylketimines was developed. With a rhodium/diene complex as catalyst, high enantioselectivity and broad functional group tolerance were observed. The resulting sulfamidates can easily be converted into chiral β-alkyl-β-aryl amino alcohols.