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Enantioselective Organocatalytic Michael Addition of Nitroalkanes and Other Nucleophiles to β‑Trifluoromethylated Acrylamides

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posted on 05.04.2013, 00:00 by Lele Wen, Liang Yin, Qilong Shen, Long Lu
An organocatalytic asymmetric Michael addition of nitroalkanes to trifluoromethylated acrylamides in good yields and with good to excellent diastereoselectivities and excellent enantioselectivities is described. The Michael adducts could be readily transformed into optically pure trifluoromethylated γ-aminobutyric acid 7 in high yields without loss in enantioselectivities.