Enantioselective N‑Heterocyclic Carbene-Catalyzed Synthesis of Trifluoromethyldihydropyridinones

The enantioselective N-heterocyclic carbene-catalyzed [4 + 2] cyclocondensation of α-chloroaldehydes and trifluoromethyl N-Boc azadienes was developed, giving the corresponding 3,4-disubstituted-6-trifluoromethyldihydropyridin-2­(1H)-ones in good yields with exclusive cis-selectivities and excellent enantioselectivities.