ja105111n_si_003.cif (18.81 kB)

Enantioselective Construction of Spiroindolenines by Ir-Catalyzed Allylic Alkylation Reactions

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posted on 25.08.2010, 00:00 by Qing-Feng Wu, Hu He, Wen-Bo Liu, Shu-Li You
With 2-methyl-1,2,3,4-tetrahydroquinoline-derived phosphoramidite ligand (R,Ra)-L6, Ir-catalyzed intramolecular C-3 allylic alkylation of indoles has been realized to afford highly enantioenriched spiroindolenine derivatives in 92−98% yields with up to >99/1 dr and 97% ee.

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