ol202527g_si_001.cif (19.65 kB)

Enantioselective Bromocyclization of Olefins Catalyzed by Chiral Phosphoric Acid

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posted on 22.02.2016, 11:22 by Deshun Huang, Haining Wang, Fazhen Xue, Huan Guan, Lijun Li, Xianyou Peng, Yian Shi
A chiral phosphoric acid catalyzed enantioselective bromocyclization of olefins is described. Various cis-, trans-, or trisubstituted γ-hydroxy-alkenes and γ-amino-alkenes can cyclize under the reaction conditions to give optically active 2-substituted tetrahydrofurans and tetrahydropyrroles in up to 91% ee.