Efficient Microwave-Assisted Synthesis of Amine-Substituted Tetrakis(pentafluorophenyl)porphyrin

We report an efficient and rapid means for the synthesis of tetrakis(pentafluorophenyl)porphyrin (TPPF₂₀) derivatives by microwave irradiation in an environmentally acceptable solvent. The selective displacement of the para-fluorine groups in TPPF₂₀ by primary amines occurs in yields between 70 and 95%. This method demonstrates that TPPF₂₀ is an ideal platform for the rapid formation of porphyrin conjugates for therapeutic, catalytic, and other applications.