Efficient Microwave-Assisted Synthesis of Amine-Substituted Tetrakis(pentafluorophenyl)porphyrin
datasetposted on 26.10.2006 by Diana Samaroo, Clifford E. Soll, Louis J. Todaro, Charles M. Drain
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We report an efficient and rapid means for the synthesis of tetrakis(pentafluorophenyl)porphyrin (TPPF20) derivatives by microwave irradiation in an environmentally acceptable solvent. The selective displacement of the para-fluorine groups in TPPF20 by primary amines occurs in yields between 70 and 95%. This method demonstrates that TPPF20 is an ideal platform for the rapid formation of porphyrin conjugates for therapeutic, catalytic, and other applications.