ol501312s_si_001.cif (17.75 kB)
Dual Roles of Sulfonyl Hydrazides: A Three-Component Reaction To Construct Fully Substituted Pyrazoles Using TBAI/TBHP
dataset
posted on 2014-06-20, 00:00 authored by Jie Zhang, Ying Shao, Hongxiang Wang, Qiang Luo, Jijun Chen, Dongmei Xu, Xiaobing WanA mild
and rapid approach has been developed for the construction
of fully substituted pyrazoles using TBAI as a catalyst and TBHP as
an oxidant, in which tosylhydrazide functions as the ring component
and sulfonyl precursor. This protocol features a wide substrate scope
with a broad range of functional group tolerance, utilizes easily
available starting materials, can be scaled-up, and is operationally
simple.
