American Chemical Society
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Dual Roles of Sulfonyl Hydrazides: A Three-Component Reaction To Construct Fully Substituted Pyrazoles Using TBAI/TBHP

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posted on 2014-06-20, 00:00 authored by Jie Zhang, Ying Shao, Hongxiang Wang, Qiang Luo, Jijun Chen, Dongmei Xu, Xiaobing Wan
A mild and rapid approach has been developed for the construction of fully substituted pyrazoles using TBAI as a catalyst and TBHP as an oxidant, in which tosylhydrazide functions as the ring component and sulfonyl precursor. This protocol features a wide substrate scope with a broad range of functional group tolerance, utilizes easily available starting materials, can be scaled-up, and is operationally simple.