American Chemical Society
ol060530l_si_002.cif (24.46 kB)

Double Lawton SN2‘Addition to Epoxyvinyl Sulfones:  Selective Construction of the Stereotetrads of Aplyronine A

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posted on 2006-07-06, 00:00 authored by Ahmad El-Awa, Philip Fuchs
Enantiopure epoxyvinyl sulfones function as templates for the diastereoselective construction of the three stereotetrads of aplyronine A. Lawton SN2‘ addition of 3,5-dimethylpyrazole followed by its displacement in an alcohol-directed Lawton SN2‘ reaction establishes the required product stereochemistry with high selectivity.