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Double C(sp3)–H Bond Functionalization Mediated by Sequential Hydride Shift/Cyclization Process: Diastereoselective Construction of Polyheterocycles

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posted on 12.03.2014, 00:00 authored by Keiji Mori, Kazuki Kurihara, Shinnosuke Yabe, Masahiro Yamanaka, Takahiko Akiyama
Described herein are two novel types of double C­(sp3)–H bond functionalizations triggered by a sequential hydride shift/cyclization process: (1) construction of a bicyclo[3.2.2]­nonane skeleton by a [1,6]- and [1,5]-hydride shift sequence and (2) sequential [1,4]- and [1,5]-hydride shift mediated construction of a linear tricyclic skeleton.