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Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment

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posted on 23.09.2011, 00:00 by Mostafa E. Rateb, Wael E. Houssen, William T. A. Harrison, Hai Deng, Chinyere K. Okoro, Juan A. Asenjo, Barbara A. Andrews, Alan T. Bull, Michael Goodfellow, Rainer Ebel, Marcel Jaspars
The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A–C (13). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 13 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.

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