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Direct Generation of Ti-Enolate of α-CF3 Ketone:  Theoretical Study and High-Yielding and Diastereoselective Aldol Reaction

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posted on 20.10.2004, 00:00 authored by Yoshimitsu Itoh, Masahiro Yamanaka, Koichi Mikami
Success in the direct generation of the Ti-enolate of α-CF3 ketone and its aldol reaction is reported. The importance of Ti−F interaction during the course of the reaction is also reported.