Direct C−H Arylation of (Hetero)arenes with Aryl Iodides via Rhodium Catalysis
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posted on 2006-09-13, 00:00 authored by Shuichi Yanagisawa, Tomoko Sudo, Ryoji Noyori, Kenichiro ItamiA new method for the catalytic C−H arylation of heteroarenes and arenes that manifests high activity paired with reasonably broad scope was developed. Under the catalytic influence of RhCl(CO){P[OCH(CF3)2]3}2 and Ag2CO3, the direct C−H arylation of heteroarenes/arenes with aryl/heteroaryl iodides took place to afford a range of biaryls in good to excellent yields with high regioselectivity. Thiophenes, furans, pyrroles, indoles, and alkoxybenzenes are applicable in this arylation protocol.
