American Chemical Society
np4004799_si_001.cif (26.92 kB)

Dioxatricyclic and Oxabicyclic Polyketides from Trichocladium opacum

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posted on 2014-01-24, 00:00 authored by Shenxi Chen, Fengxia Ren, Shubin Niu, Xingzhong Liu, Yongsheng Che
Five new polyketides, trichocladinols D–H (15) with dioxatricyclic (13) and oxabicyclic (4 and 5) skeletons, and the known massarilactone C (6) were isolated from the solid-substrate fermentation cultures of the ascomycete fungus Trichocladium opacum. The structures of 15 were determined mainly by NMR experiments, and 1, 3, and 4 were confirmed by X-ray crystallography. The absolute configurations of 1 and 3 were assigned by X-ray crystallography using Cu Kα radiation, whereas that of C-5 in 2 and 4 was deduced via the circular dichroism (CD) data. Compounds 24 showed weak cytotoxicity against the human tumor cell lines A549, HCT116, and SW480.